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    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 2; Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(May-Jun, 2021)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Mucinosis: Treatment with Radiation Therapy A Case Report</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>6</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Jonathan</FirstName>
          <LastName>Roubil</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kara</FirstName>
          <LastName>Banson</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>James</FirstName>
          <LastName>Shen</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kevin</FirstName>
          <LastName>O’Connor</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kelly Fournier</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Andrea Hebert</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Raymond Geitler</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Thomas Quinn</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Carla</FirstName>
          <LastName>Bradford</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Nadine</FirstName>
          <LastName>Bayless</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Erica Smith</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Samantha Boudreau</FirstName>
          <LastName>RT(T)</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Allison</FirstName>
          <LastName>Sacher</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Jesse</FirstName>
          <LastName>Aronowitz</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Paul</FirstName>
          <LastName>Rava</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Maryann</FirstName>
          <LastName>Bishop-Jodoin</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Harry</FirstName>
          <LastName>Bushe</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Linda</FirstName>
          <LastName>Ding</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>TJ</FirstName>
          <LastName>FitzGerald</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Mucin is a hyaluronic acid complex found in modest quantity in dermal connectives tissues. It serves as a protective barrier and supports tissue elasticity. Mucin has an important role as a response vehicle to injury and trauma in multiple body regions. Although thought to be produced by connective tissue, fibroblasts, and mast cells, the origin and regulatory mechanisms associated with production and absorption of mucin are largely unknown. Accumulation of unregulated large volumes of mucin in subcutaneous tissues can result in pain and limited wound healing when tissues over saturated with mucin are injured. Repair systems are less effective in edematous tissue as cell systems required for healing cannot accumulate at the site of injury in an organized enterprise manner. Clinically relevant forms of mucinosis have been described in hypothyroidism, thyrotoxicosis, and scleromyxedema associated with monoclonal gammopathies. Mucinosis has also been associated with systemic lupus, systemic sclerosis, and dermatomyositis including patients treated with chemoradiotherapy. In this paper we present a case report of an individual who had exhausted traditional therapies for mucinosis associated with an underlying thyroid disorder and had significant difficulty walking due to pain and discomfort in both her feet and distal lower extremities. We report on successful application of radiation therapy to effectively treat her symptoms.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Mucinosis,Radiation Therapy</Keywords>
      <URLs>
        <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=13014&amp;title=Mucinosis: Treatment with Radiation Therapy A Case Report</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Apisarnthanarax N, Ha CS, Duvic M. Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation: successful treatment using radiation therapy plus oral bexarotene combination therapy. American Journal of Clinical Dermatology 2003; 4: 429-433.&#13;
&#13;
Biondo G, Sola S, Pastorino C, Massone C. Clinical, dermoscopic, and histologic aspects of two cases of cutaneous focal mucinosis. Anais Brasileiros de Dermatologia 2019; 94: 334-336.&#13;
&#13;
Bonta MD, Tannous ZS, Demierre MF, Gonzalez E, Harris NL, Duncan LM. Rapidly progressing mycosis fungoides presenting as follicular mucinosis. Journal of the American Academy of Dermatology 2000; 43: 635-640.&#13;
&#13;
Cohen PR, Erickson CP, Calame A. Case report and review of solitary cutaneous focal mucinosis: a unique primary cutaneous mucinosis unrelated to mucinosis- associated systemic diseases. Dermatology Online Journal 2020; 26(8).&#13;
&#13;
Dolenc-Voljc M, Jurcic V, Hocevar A, Tomand;scaron;ic M. Scleromyxedema with subcutaneous nodules: successful treatment with thalidomide and intravenous immunoglobulin. Case Reports in Dermatology 2013; 5: 309-315.&#13;
&#13;
Favarato MH, Miranda SS, Caleiro MT, Assad AP, Halpern I, Fuller R. Cutaneous mucinosis in mixed connective tissue disease. Anais Brasileiros de Dermatologia 2013; 88: 635-638.&#13;
&#13;
Harris JE, Purcell SM, Griffin TD. Acral persistent papular mucinosis. Journal of the American Academy of Dermatology 2004; 51: 982-988.&#13;
&#13;
Jyothirmayi R, Sittampalam Y, Harmer C. Soft tissue sarcoma of the hand and foot: conservative surgery and radiation therapy. Sarcoma 1999; 3: 17-24.&#13;
&#13;
Kuo KL, Lee LY, Kuo TT. Solitary cutaneous focal mucinosis: A clinicopathological study of 11 cases of soft fibroma-like cutaneous mucinous lesions. The Journal of Dermatology 2017; 44: 335-338.&#13;
&#13;
Rongioletti F and Rebora A. Cutaneous mucinoses: microscopic criteria for diagnosis. The American Journal of Dermatopathology 2001b; 23: 257-267.&#13;
&#13;
Rongioletti F and Rebora A. Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. Journal of the American Academy of Dermatology 2001a; 44: 273-281.&#13;
&#13;
Rongioletti F. Lichen myxedematosus (papular mucinosis): new concepts and perspectives for an old disease. Seminars in Cutaneous Medicine and Surgery 2006; 25: 100-104.&#13;
&#13;
Singh S, Kanwar AJ, Saikia UN. Scleromyxoedema with disseminated subcutaneous nodules: rare presentation of an uncommon dermatosis. Clinical and Experimental Dermatology 2013; 38: 36-39.</References>
      </References>
    </Journal>
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