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  <Article>
    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 2; Issue 6</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(Nov-Dec, 2021)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Alpelisib After Treatment with CDK4/6i and Aromatase Inhibitor: Case Report</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>6</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Agnieszka</FirstName>
          <LastName>Mlodzinska</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Agnieszka</FirstName>
          <LastName>Jagiello-Gruszfeld</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Alpelisib is an oral drug, a phosphatidylinositol 3 kinase inhibitor (PI3K) which plays a fundamental role in the cancer process. In May 2019 Alpelisib in combination with fulvestrant was approved by FDA in treatment of PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer. Since 2020 the drug has also recommendation of European Medicines Agency (EMA). The following is a case of a patient with primary metastatic breast cancer who was treated with alpelisib in combination with fulvestrant after prior chemotherapy and an aromatase inhibitor with ribociclib, obtaining a significant clinical benefit.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Metastatic Breast Cancer,Alpelisib,PIK3CA Mutation</Keywords>
      <URLs>
        <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=13461&amp;title=Alpelisib After Treatment with CDK4/6i and Aromatase Inhibitor: Case Report</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
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      </References>
    </Journal>
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