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  <Article>
    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 4; Issue 3</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(May-Jun, 2023)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Digital Gangrene: A Rare Cutaneous Manifestation of Systemic Lupus Erythematosus in The Absence of Anti-Phospholipid Antibodies</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>9</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Lamia</FirstName>
          <LastName>Bengherbia</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Said</FirstName>
          <LastName>Taharboucht</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Oussama</FirstName>
          <LastName>Souas</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Nadia</FirstName>
          <LastName>Touati</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Hassina</FirstName>
          <LastName>Chicha</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Ahcene</FirstName>
          <LastName>Chibane</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Distal gangrene is a rare and serious manifestation of systemic lupus (LS). Secondary to vasculitis, this complication is most frequently associated with the presence of antipospholipid antibodies. Gangrene affecting all four extremities at the same time is exceptional in addition in the absence of antiphospholide antibodies. We report the observation of a 52-year-old patient with an LS for 16 years, who presented for necrosis of the four extremities of simultaneous installation evolving for 01 month. In addition to the noted dry gangrene, she had peripheral sensorimotor neuropathy in the lower extremities. Despite general corticosteroid therapy, its management required amputation of the fingers and forefeet. We also propose a review of the literature with an analysis of the cases reported to date, i.e. 85 cases including our observation.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Lupus,Digital Necrosis,Gangrene,Vasculitis,Peripheral Neuropathy</Keywords>
      <URLs>
        <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=14613&amp;title=Digital Gangrene: A Rare Cutaneous Manifestation of Systemic Lupus Erythematosus in The Absence of Anti-Phospholipid Antibodies</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
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      </References>
    </Journal>
  </Article>
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