<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 1; Issue 4</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(Jul-Aug, 2020)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>Burkitt Lymphoma in Children: An Unusual Presentation</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>7</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Carmela</FirstName>
          <LastName>Brillantino</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Eugenio</FirstName>
          <LastName>Rossi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Rocco</FirstName>
          <LastName>Minelli</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Delfina</FirstName>
          <LastName>Bifano</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Elio</FirstName>
          <LastName>Bignardi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Raffaele</FirstName>
          <LastName>Zeccolini</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Massimo</FirstName>
          <LastName>Zeccolini</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>Burkitt lymphoma is an extremely aggressive and fast-growing mature B-cell non-Hodgkin lymphoma. There are three clinical variants of Burkitt__ampersandsign#39;s lymphoma: endemic or African, sporadic and related to immunodeficiency. The sporadic variant of Burkitt__ampersandsign#39;s lymphoma is mainly present in Western countries and represents 40% of all childhood non-Hodgkin lymphomas. The average age of onset is 8 years. In pediatric age, sporadic Burkitt lymphoma is mainly an extranodal disease and at diagnosis the most commonly involved site is the gastrointestinal system, in the form of a massive abdominal mass occupying the lower right quadrant and which arises in the region of the ileocecal valve. Sporadic Burkitt lymphoma occurs less frequently with cervical lymphadenopathies, and other organs such as the brain, lung, liver, spleen, kidney and bone are commonly affected in the systemic spread of the tumor. In this article we describe an unusual presentation of advanced LB. A 5-year-old boy came to our observation due to a left submandibular lymph node swelling that was biopsied with the diagnosis of LB. Subsequently, radiological investigations performed for staging unexpectedly showed liver, kidney and brain injuries.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>Burkitt lymphoma,Meningeal infiltrates,Ultrasound,CT,MRI</Keywords>
      <URLs>
        <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=7545&amp;title=Burkitt Lymphoma in Children: An Unusual Presentation</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Abramson SJ and Price AP. Imaging of pediatric lymphomas. Radiol Clin North Am 2008; 46: 313-338.&#13;
&#13;
Biko DM, Anupindi SA, Hernandez A, Kersun L, Bellah R. Childhood Burkitt lymphoma: abdominal and pelvic imaging findings. AJR Am J Roentgenol 2009; 192: 1304–1315.&#13;
&#13;
Brillantino C, Rossi E, Bifano D, Minelli R, Tamasi S, Mamone R, Bignardi E, Zeccolini R, Zeccolini M, Vallone G. An unusual onset of pediatric acute lymphoblastic leukemia. J Ultrasound 2020; 23: 1-6&#13;
&#13;
Camilo GB, Machado DC, de Oliveira CE, Lacerda Lda S, de Oliveira RV, Silva Mde F, Lopes AJ. Burkitt lymphoma with initial clinical presentation due to infiltration of the central nervous system and eye orbits. Am J Case Rep 2014; 15: 404-410.&#13;
&#13;
Caprio MG, Di Serafino M, Pontillo G, Vezzali N, Rossi E, Esposito F, Zeccolini M, Vallone G. Paediatric neck ultrasonography: a pictorial essay. J Ultrasound 2019; 22: 215-226.&#13;
&#13;
Derinkuyu BE, Boyuna?a and;Ouml;, and;Ouml;ztunal? and;Ccedil;, Tekke?in F, Damar and;Ccedil;, Al?ml? AG, Okur A. Imaging features of Burkitt lymphoma in pediatric patients. Diagn Interv Radiol 2016; 22: 95-100.&#13;
&#13;
Di Serafino M, Severino R, Gioioso M, Rossi E, Vezzali N, Pelliccia P, Caprio MG, Acampora C, Iorio R, Vallone G. Paediatric liver ultrasound: a pictorial essay. J Ultrasound 2020; 23: 87-103.&#13;
&#13;
Huang MS, Tarbell NJ, Weinstein HJ. Chapter 8. p. 167: Non-Hodgkin Lymphoma. In: Halperin EC, Constine LS, Tarbell NJ, Kun LE, editors. Pediatric Radiation Oncology. 5th ed. Philadelphia: Lippincott Williams and Wilkins Publishers, 2010.&#13;
&#13;
Kalisz K, Alessandrino F, Beck R, Smith D, Kikano E, Ramaiya NH, Tirumani SH. An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence. Insights Imaging 2019; 10: 56.&#13;
&#13;
Lloyd C and McHugh K. The role of radiology in head and neck tumours in children. Cancer Imaging 2010; 10: 49–61.&#13;
&#13;
Malhotra A, Tu L, Kalra VB, Wu X, Mian A, Mangla R, Michaelides E, Sanelli P, Gandhi D. Neuroimaging of Meckeland;#39;s cave in normal and disease conditions. Insights Imaging 2018; 9: 499-510.&#13;
&#13;
Mukhtar F, Boffetta P, Risch HA, Park JY, Bubu OM, Womack L, Tran TV, Zgibor JC, Luu HN. Survival predictors of Burkitt’s lymphoma in children, adults and elderly in the United States during 2000–2013. Int J Cancer 2017; 140: 1494-1502.&#13;
&#13;
Pessey JJ, Rose X, Vergez S. Cervical adenopathies. EMC-Otolaryngology 2009; 8: 1-14.&#13;
&#13;
Toma P, Granata C, Rossi A, Garaventa A. Multimodality Imaging of Hodgkin Disease and Non-Hodgkin Lymphomas in Children. Radiographics 2007; 27: 1335-1354.</References>
      </References>
    </Journal>
  </Article>
</ArticleSet>