<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
<Article>
<Journal>
<PublisherName>jmedicalcasereports</PublisherName>
<JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Volume 1; Issue 5</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>(Sep-Oct, 2020)</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>-0001</Year>
<Month>11</Month>
<Day>30</Day>
</PubDate>
<ArticleType>Medical Case Reports</ArticleType>
<ArticleTitle>Spontaneous Spleen Rupture: An Unexpected Consequence of Infectious Mononucleosis - A Case Report</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>1</FirstPage>
<LastPage>10</LastPage>
<AuthorList>
<Author>
<FirstName>Sincaryl</FirstName>
<LastName>Tchouankeu</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Anne-Catherine</FirstName>
<LastName>Gérard</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Ides M</FirstName>
<LastName>Colin</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
</AuthorList>
<DOI/>
<Abstract>A 28-year-old man, with no remarkable previous medical history, was admitted in the emergency room for fever, odynophagia and colitis-like symptoms. A blood test showed neutrophilic hyperleukocytosis. An abdominal CT scan showed splenomegaly, and rupture of the spleen which prompted a surgical procedure. A posteriori blood serology examination showed increased immunoglobulins type IgM for cytomegalovirus (CMV) and Epstein Barr virus (EBV). There was no history of previous trauma. Spontaneous spleen rupture secondary to EBV infection-associated splenomegaly is a rare medical condition. It can be life-threatening and represents a diagnostic challenge as it may sometimes occur months after the viral infection. In addition it can occur without clinical signs of hemodynamic shock. The inversion of the leukocyte formula contributes to the diagnosis. The clinical presentation, the diagnostic, and the therapeutic strategy for spontaneous splenic rupture are discussed. The prophylactic management of splenectomized patients is also discussed.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Spleen,Spontaneous Spleen Rupture,Splenomegaly,Splenectomy,Infectious Mononucleosis,Colitis-Like Symptoms,Diagnosis,Overwhelming Post-Splenectomy Infection (OPSI)</Keywords>
<URLs>
<Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=8237&title=Spontaneous Spleen Rupture: An Unexpected Consequence of Infectious Mononucleosis - A Case Report</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>Bartlett A, Williams R, Hilton M. Splenic rupture in infectious mononucleosis: A systematic review of published case reports. Injury 2016; 47: 531-538.
Buzeland;eacute; R, Barbier L, Sauvanet A, Fantin B. Medical complications following splenectomy. /data/revues/18787886/v153i4/S1878788616300297/. Published online August 30, 2016. Accessed June 14, 2020. https://www.em-consulte.com/en/article/1076888
Contou D, Coudroy R, Colin G, Tadiand;eacute; JM, Cour M, Sonneville R, Dessap AM, de Prost N. Pneumococcal purpura fulminans in asplenic or hyposplenic patients: a French multicenter exposed-unexposed retrospective cohort study. Crit Care 2020; 24: 68.
Dahyot-Fizelier C, Debaene B, Mimoz O. Management of infection risk in asplenic patients. Ann Fr Anesth Reanim 2013; 32: 251-256.
Davidson RN and Wall RA. Prevention and management of infections in patients without a spleen. Clin Microbiol Infect 2001; 7: 657-660.
Ebell MH, Call M, Shinholser J, Gardner J. Does this patient have infectious mononucleosis?: the rational clinical examination systematic review. JAMA 2016; 315: 1502-1509.
Gand;ouml;rg C, Cand;ouml;lle J, Gand;ouml;rg K, Prinz H, Zugmaier G. Spontaneous rupture of the spleen: ultrasound patterns, diagnosis and follow-up. Br J Radiol 2003; 76: 704-711.
Grover SA, Barkun AN, Sackett DL. The rational clinical examination. Does this patient have splenomegaly? JAMA 1993; 270: 2218-2221.
Hosey RG, Kriss V, Uhl TL, DiFiori J, Hecht S, Wen DY. Ultrasonographic evaluation of splenic enlargement in athletes with acute infectious mononucleosis. Br J Sports Med 2008; 42: 974-977.
Ishii T, Sasaki Y, Maeda T, Komatsu F, Suzuki T, Urita Y. Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: A single-center case-control study in Japan. J Infect Chemother 2019; 25: 431-436.
Jeevan K, Akshay S. Asymptomatic spontaneous splenic rupture – a hair-raising experience in the operating room. The internet Joournal of surgery 2008; 20: 5.
Jehangir A, Poudel DR, Masand-Rai A, Donato A. A systematic review of splenic injuries during colonoscopies: Evolving trends in presentation and management. Int J Surg 33: 55-59.
Klein EY, Monteforte B, Gupta A, Jiang W, May L, Hsieh YH, Dugas A. The frequency of influenza and bacterial coinfection: a systematic review and meta?analysis. Influenza Other Respir Viruses 2016; 10: 394-403.
Kucyba?a I, Ciuk S, T?czar J. Spleen enlargement assessment using computed tomography: which coefficient correlates the strongest with the real volume of the spleen? Abdom Radiol (NY) 2018; 43: 2455-2461.
Morse SA. Neisseria, Moraxella, Kingella and Eikenella. In: Baron S, ed. Medical Microbiology. 4th ed. University of Texas Medical Branch at Galveston; 1996. Accessed June 15, 2020.
Musher DM. Haemophilus Species. In: Baron S, ed. Medical Microbiology. 4th ed. University of Texas Medical Branch at Galveston; 1996. Accessed June 15, 2020.
Olson APJ, Trappey B, Wagner M, Newman M, Nixon LJ, Schnobrich D. Point-of-care ultrasonography improves the diagnosis of splenomegaly in hospitalized patients. Crit Ultrasound J 2015; 7: 13.
Patterson MJ. Streptococcus. In: Baron S, ed. Medical Microbiology. 4th ed. University of Texas Medical Branch at Galveston; 1996. Accessed June 15, 2020.
Renzulli P, Hostettler A, Schoepfer AM, Gloor B, Candinas D. Systematic review of atraumatic splenic rupture. Br J Surg 2009; 96: 1114-1121
Rodeghiero F and Ruggeri M. Short- and long-term risks of splenectomy for benign haematological disorders: should we revisit the indications? Br J Haematol 2012; 158: 16-29.
Serra LC, York LJ, Gamil A, Balmer P, Webber C. A Review of Meningococcal Disease and Vaccination Recommendations for Travelers. Infect Dis Ther 2018; 7: 219-234.
Sinwar PD. Overwhelming post splenectomy infection syndrome - review study. Int J Surg 2014; 12: 1314-1316.
Smith EB, Custer RP. Rupture of the spleen in infectious mononucleosis: a clinicopathologic report of seven cases. Blood 1946; 1: 317-333.
Sohn MJ, Cho JM, Moon JS, Ko JS, Yang HR. EBV VCA IgM and cytomegalovirus IgM dual positivity is a false positive finding related to age and hepatic involvement of primary Epstein-Barr virus infection in children. Medicine (Baltimore) 2018; 97: e12380.
Sylvester JE, Buchanan BK, Paradise SL, Yauger JJ, Beutler AI. Association of Splenic Rupture and Infectious Mononucleosis: A Retrospective Analysis and Review of Return-to-Play Recommendations. Sports Health 2019; 11: 543-549.
Tahir F, Ahmed J, Malik F. Post-splenectomy Sepsis: A Review of the Literature. Cureus 2020; 12: e6898.
Theilacker C, Ludewig K, Serr A, Schimpf J, Held J, Band;ouml;gelein M, Bahr V, Rusch S, Pohl A, Kogelmann K, Frieseke S. Overwhelming postsplenectomy infection: a prospective multicenter cohort study. Clin Infect Dis 2016; 62: 871-878.
Zhang YY, Tang XF, Du CH, Wang BB, Bi ZW, Dong BR. Comparison of dual influenza and pneumococcal polysaccharide vaccination with influenza vaccination alone for preventing pneumonia and reducing mortality among the elderly: A meta-analysis. Hum Vaccin Immunother 2016; 12: 3056-3064.</References>
</References>
</Journal>
</Article>
</ArticleSet>