<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>jmedicalcasereports</PublisherName> <JournalTitle>Frontiers in Medical Case Reports</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 2; Issue 3</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(May-Jun, 2021)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Medical Case Reports</ArticleType> <ArticleTitle>POEMS Syndrome Presenting with Fever, Diarrhea and Progressive Fatigue: A Case Report</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>6</LastPage> <AuthorList> <Author> <FirstName>Fang</FirstName> <LastName>Chen</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Heng</FirstName> <LastName>Jin</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Song-Tao</FirstName> <LastName>Shou</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>We report a successful diagnosis of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) patient who presented with fever, diarrhea and progressive fatigue in the lower limbs. The aim of this case report is to enhance the awareness of POEMS syndrome. When clinicians encounter a patient with unexplained peripheral neuropathy or multisystem disorders, and also suffers from diabetes mellitus or other endocrinopathy, detailed examinations should be performed to rule out POEMS syndrome.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>POEMS Syndrome,Fatigue,VEGF,Polyneuropathy</Keywords> <URLs> <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=13013&title=POEMS Syndrome Presenting with Fever, Diarrhea and Progressive Fatigue: A Case Report</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Ali T and Qazilbash MH. POEMS syndrome: A multisystem clonal disorder. Eur J Haematol 2021; 106: 14-18. Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine 1980; 59: 311-322. Chang T. Guidelines for diagnosis and treatment of myasthenia gravis in China 2020. Chinese Journal of Neuroimmunology and Neurology 2020; 201: 1-12. Dispenzieri A. and;#39;Poems Syndrome: 2019 Update on Diagnosis, Risk-Stratification, and Managementand;#39;. Am J Hematol 2019; 94: 812-827. Kamezaki K and Nagafuji K. POEMS syndrome: monoclonal plasma cell disorder with polyneuropathy. Nihon Rinsho 2007; 65: 2235-2237. LIN Guowei, WANG Jiyao, GE Junbo. Practical Internal Medicine 15th Edition. Science Technology and Publishing House 2017: 2. Marsh ES, Keddie S, Terris-Prestholt F, Dand;#39;Sa S, Lunn MP. Early VEGF testing in inflammatory neuropathy avoids POEMS syndrome misdiagnosis and associated costs. J Neurol Neurosurg Psychiatry 2021; 92: 172-176. Nasu S, Misawa S, Sekiguchi Y, Shibuya K, Kanai K, Fujimaki Y, Ohmori S, Mitsuma S, Koga S, Kuwabara S. Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Neurosurg Psychiatry 2012; 83: 476-479. Nozza A, Terenghi F, Gallia F, Adami F, Briani C, Merlini G, Giordano L, Santoro A, Nobile-Orazio E. Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. Br J Haematol 2017; 179: 748-755. Pihan M, Keddie S, Dand;#39;Sa S, Church AJ, Yong KL, Reilly MM, Lunn MP. Raised VEGF: High sensitivity and specificity in the diagnosis of POEMS syndrome. Neurol Neuroimmunol Neuroinflamm 2018; 5: e486. Shi Xiaoyan, Peng Hongju, Sun Guozhen. A case of POEMS syndrome with a large amount of ascites as the main manifestation and literature review. Journal of Shandong University 2021; 59: 114-117. Wang C, Huang XF, Cai QQ, Cao XX, Duan MH, Cai H, Zhou DB, Li J. Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome. Leukemia 2017; 31: 100-106. Wang Y, Huang LB, Shi YH, Fu H, Xu Z, Zheng GQ, Wang Y. Characteristics of 1946 Cases of POEMS Syndrome in Chinese Subjects: A Literature-Based Study. Front Immunol 2019; 10: 1428. Wu Pingping, Cai Wenqin, Lin Xiaozhen. A case of POEMS syndrome with numbness and proteinuria in both lower limbs. Chinese Journal of Hypertension 2020; 28: 1229-1233. Yang Guangwei and Deng Nan. Clinical efficacy of methylprednisolone combined with gamma globulin in the treatment of acute Guillain-Barre syndrome. Journal of Clinical Medicine 2019; A1: 69-70.</References> </References> </Journal> </Article> </ArticleSet>