<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>jmedicalcasereports</PublisherName> <JournalTitle>Frontiers in Medical Case Reports</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 3; Issue 1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(Jan-Feb, 2022)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Medical Case Reports</ArticleType> <ArticleTitle>Insulin Delivery Utilizing Hybrid-Closed-Loop Therapy is More Effective When a Single Basal Rate Rather Than Multiple Basal Rates is Utilized - A Case Report</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>4</LastPage> <AuthorList> <Author> <FirstName>David S. H.</FirstName> <LastName>Bell</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Terri</FirstName> <LastName>Jerkins</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>With Continuous Subcutaneous Insulin Infusion (CSII) multiple basal rates need to be utilized to avoid nocturnal hypoglycemia, the dawn phenomenon, postprandial hyperglycemia and preprandial hypoglycemia. With the availability of the Hybrid Closed-Loop Therapy (HCLT) systems, the use of multiple basal rates has become unnecessary and counterproductive. When transferring to a HCLT system we utilize a single basal rate for twenty-four hours. By utilizing a single basal rate we have improved multiple metrics of glycemic control in many patients. To illustrate the benefits of transfer to a single basal rate in a HCLT system we present a relevant case.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Continuous Subcutaneous Insulin Infusion,Hybrid Closed-Loop Therapy,Multiple Basal Rates,Single Basal Rate</Keywords> <URLs> <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=13588&title=Insulin Delivery Utilizing Hybrid-Closed-Loop Therapy is More Effective When a Single Basal Rate Rather Than Multiple Basal Rates is Utilized - A Case Report</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Bell DSH. Insulin pump therapy for the 90’s. The Endocrinologist 1994; 4: 270-278. Brownlee M and Hirsch IB. Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications. JAMA 2006; 295: 1707-1708. Campbell PJ, Bolli GB, Cryer PE, Gerich JE. Pathogenesis of the dawn phenomenon in patients with insulin-dependent diabetes mellitus. Accelerated glucose production and impaired glucose utilization due to nocturnal surges in growth hormone secretion. N Engl J Med 1985; 312: 1473-1479. Grunberger G, Handelsman Y, Bloomgarden ZT, Fonseca VA, Garber AJ, Haas RA, Roberts VL, Umpierrez GE. American Association of Clinical Endocrinologists and American College of Endocrinology 2018 Position Statement on Integration of Insulin Pumps and Continuous Glucose Monitoring in Patients with Diabetes Mellitus. Endocr Pract 2018; 24: 302-308. Leelarathna L, Choudhary P, Wilmot EG, Lumb A, Street T, Kar P, Ng SM. Hybrid closed-loop therapy: Where are we in 2021? Diabetes Obes Metab 2021; 23: 655-660. Tamborlane WV, Sherwin RS, Genel M, Felig P. Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med 1979; 300: 573-578. Usoh CO, Johnson CP, Speiser JL, Bundy R, Dharod A, Aloi JA. Real-World Efficacy of the Hybrid Closed-Loop System. J Diabetes Sci Technol 2021; 11: 1932296820985103.</References> </References> </Journal> </Article> </ArticleSet>