<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
<Article>
<Journal>
<PublisherName>jmedicalcasereports</PublisherName>
<JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Volume 5; Issue 4</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>(Jul-Aug, 2024)</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>-0001</Year>
<Month>11</Month>
<Day>30</Day>
</PubDate>
<ArticleType>Medical Case Reports</ArticleType>
<ArticleTitle>Late-Onset Warfarin-Induced Skin Hemorrhagic Bullae and Spontaneous Intramural Hematomas of The Gastrointestinal Tract</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>1</FirstPage>
<LastPage>6</LastPage>
<AuthorList>
<Author>
<FirstName>Segenet Bizuneh</FirstName>
<LastName>Mengistu</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Suleiman Ayalew</FirstName>
<LastName>Belaym</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Fikadu Alemiye</FirstName>
<LastName>Molla</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Rediet Getu</FirstName>
<LastName>Degu</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Alazar Wogayehu</FirstName>
<LastName>Gebrehana</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
<FirstName>Biniam Yoannes</FirstName>
<LastName>Wotango</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
</AuthorList>
<DOI/>
<Abstract>This case report describes a 62-year-old female with a history of ischemic heart disease and atrial fibrillation on long-term warfarin therapy who presented with gastrointestinal bleeding and unusual skin manifestations. This report highlights the potential for late-onset warfarin-induced skin hemorrhagic bullae and spontaneous intramural hematoma of the gastrointestinal tract (SIHGT), underscoring the need for vigilance in patients on anticoagulation therapy.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Warfarin,Skin Necrosis,Hemorrhagic Bullae,Intramural Hematoma,Gastrointestinal Tract,Anticoagulation Therapy</Keywords>
<URLs>
<Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=15353&title=Late-Onset Warfarin-Induced Skin Hemorrhagic Bullae and Spontaneous Intramural Hematomas of The Gastrointestinal Tract</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>Bircher AJ, Harr T, Hohenstein L, Tsakiris DA. Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options. Allergy 2006; 61: 1432-1440.
Cabane J, Housset B, Imbert JC. Coumarin-induced skin necrosis associated with acquired protein S deficiency and antiphospholipid antibody syndrome. Arthritis Rheum 1994; 37: 1096-1100.
Carkman S, Ozben V, Saribeyoglu K, Somuncu E, Erguney S, Korman U, et al. Spontaneous intramural hematoma of the small intestine. Ulus Travma Acil Cerrahi Derg 2010; 16: 165–169.
Carrilero Zaragoza G, Egea Valenzuela J, Moya Arnao M, Muand;ntilde;oz Tornero M, Jijand;oacute;n Crespand;iacute;n R, Tomas Pujante P, Iglesias Jorquera E, Parra Garcand;iacute;a J, Sand;aacute;nchez Velasco E, Pereand;ntilde;and;iacute;guez Land;oacute;pez A, Miras Land;oacute;pez M, Fuster Quiand;ntilde;onero M, Carballo and;Aacute;lvarez F. Spontaneous retroperitoneal hematoma in a patient under anticoagulant agents presenting as upper gastrointestinal bleeding. Rev Esp Enferm Dig 2016; 108: 817-818.
Chang CM, Huang HH, How CK. Acute pancreatitis with an intramural duodenal hematoma. Intern Med 2015; 54: 755–757.
DeFranzo AJ, Marasco P, Argenta LC. Warfarin-induced necrosis of the skin. Ann Plast Surg 1995, 34: 203-208.
Eichele DD, Ross M, Tang P, Hutchins GF, Mailliard M. Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease. World J Gastroenterol 2013; 19: 7205–7208.
Essex DW, Wynn SS, Jin DK. Late-onset warfarin-induced skin necrosis: case report and review of the literature. Am J Hematol 1998; 57: 233-237.
Frostick SP, Collin J, Daar AS, Kettlewell M, Nolan DJ. Non-traumatic intramural haematoma: an unusual cause of duodenal obstruction. Br J Surg 1984; 71: 313–314.
Jones WR, Hardin WJ, Davis JT, Hardy JD. Intramural hematoma of the duodenum: a review of the literature and case report. Ann Surg 1971; 173: 534-544.
Niehues SM, Denecke T, Bassir C, Hamm B, Haas M. Intramural duodenal hematoma: clinical course and imaging findings. Acta Radiol Open 2019; 8: 2058460119836256.
Tseng CY, Fan JS, Yang SC, Huang HH, Chen JD, Yen DH, Huang CI. Anticoagulant-induced intramural intestinal hemorrhage. Am J Emerg Med 2010; 28: 937–940.
Veldt BJ, Haringsma J, Florijn KW, Kuipers EJ. Coumarin-induced intramural hematoma of the duodenum: case report and review of the literature. Scand J Gastroenterol 2011; 46: 376-379
Verhagen H. Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl. Acta Med Scand 1954; 148: 453-467.
Wong K, Thomas R. A curious case of spontaneous duodenal haematoma presenting a diagnostic challenge. BMJ Case Rep 2014; 2014: bcr2013200614.</References>
</References>
</Journal>
</Article>
</ArticleSet>