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  <Article>
    <Journal>
      <PublisherName>jmedicalcasereports</PublisherName>
      <JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 6; Issue 4</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>(Jul-Aug, 2025)</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>-0001</Year>
        <Month>11</Month>
        <Day>30</Day>
      </PubDate>
      <ArticleType>Medical Case Reports</ArticleType>
      <ArticleTitle>SISCOM Findings in Atonic Seizure Due To Lennox–Gastaut Syndrome</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>1</FirstPage>
      <LastPage>5</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Darío</FirstName>
          <LastName>Lisei</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Álvaro</FirstName>
          <LastName>Baena</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Nuria</FirstName>
          <LastName>Bargalló</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Aida Niñerola-Baizan</FirstName>
          <LastName>Engineer</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Katherine</FirstName>
          <LastName>Quintero</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Antonio</FirstName>
          <LastName>Donaire</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Xavier</FirstName>
          <LastName>Setoain</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI/>
      <Abstract>The present case documents the 99mTc-HMPAO subtraction ictal SPECT and co-registered with MRI (SISCOM) high uptake in left thalamus, right caudate nucleus, left frontal and superior temporal gyrus and brainstem in a Lennox–Gastaut Syndrome (LGS) patient, supporting the notion that LGS is not solely a cortical disorder but rather involves largescale thalamocortical and striato brainstem networks.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>SISCOM,Brain SPECT,Brain PET/CT,Atonic seizure,Lennox-Gastaut Syndrome</Keywords>
      <URLs>
        <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=15843&amp;title=SISCOM Findings in Atonic Seizure Due To Lennox–Gastaut Syndrome</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References>Amuktar CV, Lui F. Lennox-Gastaut Syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.&#13;
&#13;
Poulen G, Gand;eacute;lisse P, Crespel A, Chan-Seng E, Moser PO, Coubes P. Does deep brain stimulation of the anterior nucleus of the thalamus represent the future of Lennox-Gastaut syndrome? J Neurol 2025; 272: 312.&#13;
&#13;
Velasco AL, Velasco F, Jimand;eacute;nez F, Velasco M, Castro G, Carrillo-Ruiz JD, Fanghand;auml;nel G, Boleaga B. Neuromodulation of the centromedian thalamic nuclei in the treatment of generalized seizures and the improvement of the quality of life in patients with Lennox-Gastaut syndrome. Epilepsia 2006; 47: 1203-1212.&#13;
&#13;
Velasco F, Velasco AL, Velasco M. Centromedian thalamic stimulation in intractable epilepsy: I. Clinical, electroencephalographic, and behavioral observations. Epilepsia 2000; 41: S20-S29.&#13;
&#13;
Wang Z, Zhang Z, Jiao Q, Liao W, Chen G, Sun K, Shen L, Wang M, Li K, Liu Y, Lu G. Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI. PLoS One 2012; 7: e39701.&#13;
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Zillgitt AJ, Haykal MA, Chehab A, Staudt MD. Centromedian thalamic neuromodulation for the treatment of idiopathic generalized epilepsy. Front Hum Neurosci 2022; 16: 907716.</References>
      </References>
    </Journal>
  </Article>
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