<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>jmedicalcasereports</PublisherName> <JournalTitle>Frontiers in Medical Case Reports</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 2; Issue 2</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>(Mar-Apr, 2021)</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Medical Case Reports</ArticleType> <ArticleTitle>Spongy, Nongravid Uterine Fibroid Due to Hydropic Change: Case Report and Review</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>1</FirstPage> <LastPage>7</LastPage> <AuthorList> <Author> <FirstName>Yahia F</FirstName> <LastName>Dajani</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Ali M</FirstName> <LastName>Akilah</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>We report unique regressive changes in a large, non-gravid uterine leiomyoma of a 32 year old lady who, before 2015, had had seven recurrent spontaneous, alternating with assisted pregnancies, over a 7-year period (2008-1015 AD). In formalin-fixed status, cut surface of the leiomyoma showed a sponge-like appearance. Pathogenesis of resultant degenerative changes in respect of repeated hormonal hits is discussed, together with review of the literature. To our knowledge, such extreme multi-cystic change in leiomyoma with spongy appearance has not been previously reported.</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>Non-Gravid Uterine Leiomyoma,Multi-Cystic Change,Diverse Hormonal Hits</Keywords> <URLs> <Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=9572&title=Spongy, Nongravid Uterine Fibroid Due to Hydropic Change: Case Report and Review</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References>Biomedical Research 2013; 4: 638-664. Celik ZE, Bastoklu S, Tuyan Ilhan T and Celik C. Cavernous hemangioma arising in an intramural leiomyoma. Integrative Cancer Science and Therapeutics 2017; 4 (1): 1-3. Coard K and Plummer J. Massive multilocular cystic change of the uterus. An extreme example of hydropic degeneration. South Medical Journal 2007; 100: 309-312. Horta M, Cunha TM, Oliveira R, Magro P. Hydropic leiomyoma of the uterus presenting as a giant abdominal mass. BMJ Case Reports 2015; 2015: bcr2015211929. Jashnani KD, Kim S, Dhamija G. Letter to the editor. Perinodular hydropic degeneration in leiomyoma: An alarming histology. Indian Journal of Pathology and; Microbiology 2010; 53: 173-175. Kagan Arleo E, Schwartz PE, Hui P, McCarthy S. Review of leiomyoma variants. American Journal of Roentgenology 2015; 205: 912-921. Laughlin SH and Stewart EA. Uterine Leiomyomas. Individualizing the Approach to a Heterogeneous Condition. Obstetrics and Gynecology 2011; 117: 396-403. Lee S and Park M. Thick uterine endometrium with “honeycomb” appearance in transvaginal ultrasonography revealed various gynecologic conditions: presented with flexible hysteroscopic findings. Abstract. In: Ultrasound in Obstetrics and; Gynecology. 27th World Congress on Ultrasound in Obstetrics and; Gynecology, Vienna 2017; 50: 16-19. Lewis TD, Malik M, Britten J, San Pablo AM, Catherino WH. A comprehensive review of the pharmacologic management of uterine leiomyoma. BioMedical Research International 2018; pp: 1-11. Patil AR, Nandikoors S, Padilu R. Hydropic degeneration of leiomyoma in nongravid uterus: The ‘split fiber’ sign on MRI. Indian J of Radiological Imaging 2018; 28: 182-186.</References> </References> </Journal> </Article> </ArticleSet>