<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<ArticleSet>
<Article>
<Journal>
<PublisherName>jmedicalcasereports</PublisherName>
<JournalTitle>Frontiers in Medical Case Reports</JournalTitle>
<PISSN>I</PISSN>
<EISSN>S</EISSN>
<Volume-Issue>Volume 2; Issue 2</Volume-Issue>
<PartNumber/>
<IssueTopic>Multidisciplinary</IssueTopic>
<IssueLanguage>English</IssueLanguage>
<Season>(Mar-Apr, 2021)</Season>
<SpecialIssue>N</SpecialIssue>
<SupplementaryIssue>N</SupplementaryIssue>
<IssueOA>Y</IssueOA>
<PubDate>
<Year>-0001</Year>
<Month>11</Month>
<Day>30</Day>
</PubDate>
<ArticleType>Medical Case Reports</ArticleType>
<ArticleTitle>Spongy, Nongravid Uterine Fibroid Due to Hydropic Change: Case Report and Review</ArticleTitle>
<SubTitle/>
<ArticleLanguage>English</ArticleLanguage>
<ArticleOA>Y</ArticleOA>
<FirstPage>1</FirstPage>
<LastPage>7</LastPage>
<AuthorList>
<Author>
<FirstName>Yahia F</FirstName>
<LastName>Dajani</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>N</CorrespondingAuthor>
<ORCID/>
<FirstName>Ali M</FirstName>
<LastName>Akilah</LastName>
<AuthorLanguage>English</AuthorLanguage>
<Affiliation/>
<CorrespondingAuthor>Y</CorrespondingAuthor>
<ORCID/>
</Author>
</AuthorList>
<DOI/>
<Abstract>We report unique regressive changes in a large, non-gravid uterine leiomyoma of a 32 year old lady who, before 2015, had had seven recurrent spontaneous, alternating with assisted pregnancies, over a 7-year period (2008-1015 AD). In formalin-fixed status, cut surface of the leiomyoma showed a sponge-like appearance. Pathogenesis of resultant degenerative changes in respect of repeated hormonal hits is discussed, together with review of the literature. To our knowledge, such extreme multi-cystic change in leiomyoma with spongy appearance has not been previously reported.</Abstract>
<AbstractLanguage>English</AbstractLanguage>
<Keywords>Non-Gravid Uterine Leiomyoma,Multi-Cystic Change,Diverse Hormonal Hits</Keywords>
<URLs>
<Abstract>https://www.jmedicalcasereports.org/ubijournal-v1copy/journals/abstract.php?article_id=9572&title=Spongy, Nongravid Uterine Fibroid Due to Hydropic Change: Case Report and Review</Abstract>
</URLs>
<References>
<ReferencesarticleTitle>References</ReferencesarticleTitle>
<ReferencesfirstPage>16</ReferencesfirstPage>
<ReferenceslastPage>19</ReferenceslastPage>
<References>Biomedical Research 2013; 4: 638-664.
Celik ZE, Bastoklu S, Tuyan Ilhan T and Celik C. Cavernous hemangioma arising in an intramural leiomyoma. Integrative Cancer Science and Therapeutics 2017; 4 (1): 1-3.
Coard K and Plummer J. Massive multilocular cystic change of the uterus. An extreme example of hydropic degeneration. South Medical Journal 2007; 100: 309-312.
Horta M, Cunha TM, Oliveira R, Magro P. Hydropic leiomyoma of the uterus presenting as a giant abdominal mass. BMJ Case Reports 2015; 2015: bcr2015211929.
Jashnani KD, Kim S, Dhamija G. Letter to the editor. Perinodular hydropic degeneration in leiomyoma: An alarming histology. Indian Journal of Pathology and; Microbiology 2010; 53: 173-175.
Kagan Arleo E, Schwartz PE, Hui P, McCarthy S. Review of leiomyoma variants. American Journal of Roentgenology 2015; 205: 912-921.
Laughlin SH and Stewart EA. Uterine Leiomyomas. Individualizing the Approach to a Heterogeneous Condition. Obstetrics and Gynecology 2011; 117: 396-403.
Lee S and Park M. Thick uterine endometrium with “honeycomb” appearance in transvaginal ultrasonography revealed various gynecologic conditions: presented with flexible hysteroscopic findings. Abstract. In: Ultrasound in Obstetrics and; Gynecology. 27th World Congress on Ultrasound in Obstetrics and; Gynecology, Vienna 2017; 50: 16-19.
Lewis TD, Malik M, Britten J, San Pablo AM, Catherino WH. A comprehensive review of the pharmacologic management of uterine leiomyoma. BioMedical Research International 2018; pp: 1-11.
Patil AR, Nandikoors S, Padilu R. Hydropic degeneration of leiomyoma in nongravid uterus: The ‘split fiber’ sign on MRI. Indian J of Radiological Imaging 2018; 28: 182-186.</References>
</References>
</Journal>
</Article>
</ArticleSet>